Concomitant treatment with safinamide and antidepressant drugs: Safety data from real clinical practice / Tratamiento concomitante de safinamida y antidepresivos: Datos de seguridad sobre la práctica en la vida real

Background and purpose: The aim of this study was to assess the possible pharmacological interactions between safinamide and antidepressants, and in particular the appearance of serotonin syndrome with data from real life. Methods: We conducted a retrospective observational study of patients with Parkinson's disease from our Movement Disorders Unit, who were under treatment with any antidepressant drug and safinamide. Specifically, symptoms suggestive of serotonin syndrome were screened for. Also, we collected time of simultaneous use, doses of levodopa and other antiparkinsonian drugs. Results: Clinical records were reviewed for the study period of September 2018 to September 2019. Seventy-eight PD patients who were treated with safinamide of which 25 (32.05%) had a concomitant treatment with an antidepressant drug, being sertraline and escitalopram the most frequent. Mean age was 80 years ± 8.43 and H&Y stage was 3 [2–4]. Mean dose of levodopa used was 703.75 mg ± 233.15. Median duration of concomitant treatment with safinamide and antidepressant drug was 6 months (IQR 20.5), and over eighteen months in 5 cases. No case of serotonin syndrome was recorded, neither was any of its typical manifestations combined or in isolation. Conclusions: Our real clinical practice study suggests that concomitant use of safinamide with antidepressant drugs in PD patients seemed to be safe and well tolerated, even in the long term. However, caution is warranted, individualizing treatment regimens and monitoring the potential appearance of adverse effects.(AU)

Objetivos: El objetivo de este estudio ha sido evaluar las posibles interacciones farmacológicas entre safinamida y antidepresivos; en particular la aparición del síndrome serotoninérgico mediante datos obtenidos en la vida real. Material y métodos: Realizamos un estudio observacional retrospectivo de pacientes con enfermedad de Parkinson (EP) de nuestra unidad de trastornos del movimiento, que estaban en tratamiento con algún fármaco antidepresivo y safinamida. Específicamente, se examinaron los síntomas sugestivos de síndrome serotoninérgico. Además, se recogieron tiempos de uso simultáneo, dosis de levodopa y otros fármacos antiparkinsonianos concomitantes. Resultados: Se revisaron las historias clínicas correspondientes al período de estudio de septiembre de 2018 a septiembre de 2019. Setenta y ocho pacientes con EP se encontraban en tratamiento con safinamida, de los cuales 25 (32,05%) se encontraban recibiendo además un fármaco antidepresivo, siendo sertralina y escitalopram los más frecuentes. La edad media fue de 80 años ± 8,43 y el estadio H&Y fue de 3 [2-4]. La dosis media de levodopa utilizada fue de 703,75 mg ± 233,15. La mediana de duración del tratamiento concomitante con safinamida y un fármaco antidepresivo fue de 6 meses (IQR: 20,5), y más de 18 meses en 5 casos. No se registró ningún caso de síndrome serotoninérgico, ni tampoco ninguno de sus síntomas de forma aislada. Conclusión: Nuestro estudio de práctica clínica real sugiere que el uso concomitante de safinamida con fármacos antidepresivos en pacientes con EP parece ser seguro y bien tolerado, incluso a largo plazo. Sin embargo, es necesaria precaución, individualizando los regímenes de tratamiento, y controlando la posible aparición de efectos adversos.(AU)

Concomitant treatment with safinamide and antidepressant drugs: Safety data from real clinical practice.

BACKGROUND AND PURPOSE: The aim of this study was to assess the possible pharmacological interactions between safinamide and antidepressants, and in particular the appearance of serotonin syndrome with data from real life. METHODS: We conducted a retrospective observational study of patients with Parkinson's disease from our Movement Disorders Unit, who were under treatment with any antidepressant drug and safinamide. Specifically, symptoms suggestive of serotonin syndrome were screened for. Also, we collected time of simultaneous use, doses of levodopa and other antiparkinsonian drugs. RESULTS: Clinical records were reviewed for the study period of September 2018 to September 2019. Seventy-eight PD patients who were treated with safinamide of which 25 (32.05%) had a concomitant treatment with an antidepressant drug, being sertraline and escitalopram the most frequent. Mean age was 80 years±8.43 and H&Y stage was 3 [2-4]. Mean dose of levodopa used was 703.75mg±233.15. Median duration of concomitant treatment with safinamide and antidepressant drug was 6 months (IQR 20.5), and over eighteen months in 5 cases. No case of serotonin syndrome was recorded, neither was any of its typical manifestations combined or in isolation. CONCLUSIONS: Our real clinical practice study suggests that concomitant use of safinamide with antidepressant drugs in PD patients seemed to be safe and well tolerated, even in the long term. However, caution is warranted, individualizing treatment regimens and monitoring the potential appearance of adverse effects.

Prevalence and factors associated with depression in healthcare personnel during the SARS-CoV-2 pandemic in the Department of Piura, Peru.

INTRODUCTION: The COVID-19 pandemic has increased the magnitude of mental illnesses such as depression, not only in the general population, but also in healthcare personnel. However, in Peru the prevalence, and the associated factors for developing depression in healthcare personnel, are not known. The objective was to determine the prevalence and identify the factors associated with depression in healthcare personnel, in the context of the SARS-CoV-2 pandemic. METHODS: An analytical cross-sectional study was carried out from May to September in healthcare establishments. A sample of 136 health workers were included and a survey was applied to collect the data. Depression as a dependent variable was measured using the Zung self-report scale. To identify the associated factors, the bivariate and multivariate analysis was performed by logistic regression with STATA v 14. RESULTS: The prevalence of depression was 8.8% (95%CI, 4.64-14.90). Having a family member or friend who had died from COVID-19 was associated with depression (OR = 6.78; 95%CI, 1.39-32.90; p = 0.017). Whereas the use of personal protective equipment was found to be a protective factor against developing depression (OR = 0.03; 95%CI, 0.004-0.32; p = 0.003). CONCLUSIONS: Approximately 1 in 10 healthcare professionals and technicians developed depression during the COVID-19 pandemic in this study. In addition, having relatives or friends who had died from COVID-19 was negatively associated with depression and use of personal protective equipment was identified as a protective factor.

La relación entre infertilidad y calidad del sueño en las mujeres: revisión sistemática y metaanálisis / The relationship between infertility and sleep quality in women: Systematic review and meta-analysis

Objetivos El objetivo de esta revisión sistemática y metaanálisis era examinar la relación entre la infertilidad y la calidad del sueño en las mujeres. Métodos Se realizó una búsqueda bibliográfica entre octubre y noviembre del 2022 con estudios a texto completo en PubMed (MEDLINE), Cochrane, Google Scholar y Scientific Information Database (SID). El estudio se basa en las recomendaciones del Manual Cochrane de revisiones sistemáticas de intervenciones. Los datos se analizaron mediante el programa informático Review Manager (versión 5.3). Resultados Se realizó una revisión sistemática de la literatura incluyendo 11 estudios. El metaanálisis reveló una asociación significativa entre la infertilidad y la calidad del sueño en las mujeres, con una disminución de la calidad del sueño en las pacientes infértiles (DME: –0,75; IC del 95%: –0,84 al –0,66; Z=16,46; p <0,00001) y una diferencia significativa entre infertilidad y depresión (DME: –0,18; IC del 95%: –0,27 al –0,09; Z=4,00; p <0,0001). Conclusión Según los resultados de este estudio, las mujeres infértiles tienen una calidad del sueño baja. PROSPERO ID: CRD42023404389. (AU)

Objectives This systematic review and meta-analysis study aimed to examine the relationship between infertility and sleep quality in women. Methods The literature search was conducted between October and November 2022 with full-text studies from PubMed (MEDLINE), Cochrane, Google Scholar, and Scientific Information Database (SID). The study is based on the recommendations of the Cochrane guidelines. The data were analyzed using the Review Manager computer software (Version 5.3). Results A systematic literature review was conducted, with 11 studies included. The meta-analysis revealed a significant difference between infertility and sleep quality in women, that the sleep quality of infertile patients decreased (SMD: -0.75 95% CI: -0.84 to -0.66, Z=16.46, P<.00001), and that there was a significant difference between infertility and depression (SMD: -0.18 95% CI: -0.27 to -0.09, Z=4.00, P<.0001). Conclusion The results of this study indicate that sleep quality is low in infertile women. PROSPERO ID: CRD42023404389. (AU)

Tratamiento de la depresión comórbida después de un síndrome coronario agudo: metaanálisis de ensayos controlados aleatorizados / Treatment of comorbid depression after acute coronary syndrome: meta-analysis of randomized controlled trials

La depresión postsíndrome coronario agudo (post-SCA) aumenta el riesgo cardíaco; sin embargo, la eficacia de las terapias antidepresivas para su tratamiento no está suficientemente demostrada. Nuestro objetivo es metaanalizar ensayos controlados con muestras homogéneas que permitan explicar la inconsistencia de los resultados obtenidos hasta el momento. Tras revisar 1525 artículos, dos revisores independientes identificaron 7 estudios que cumplían criterios muy restrictivos para asegurar la homogeneidad de las muestras. Los resultados indicaron que los pacientes tratados con intervenciones de eficacia demostrada para la depresión reducen sus niveles de trastorno depresivo significativamente más que los sujetos sin este tratamiento, y que existen diferencias significativas en el número de pacientes que reducen los síntomas depresivos de forma clínicamente relevante. Además, se observaron menos eventos cardiovasculares adversos durante el tratamiento, aunque esta diferencia fue mínimamente significativa y no se mantuvo tras el seguimiento. Estos resultados sugieren que la inconsistencia de los datos actualmente disponibles podría deberse a dificultades metodológicas que evidencian la necesidad de nuevas investigaciones que aclaren el efecto del tratamiento de la depresión sobre el pronóstico post-SCA.(AU)

Depression post-acute coronary syndrome (ACS) increases the cardiac risk;however, the efficacy of antidepressant therapies for its treatment has not beensufficiently demonstrated. Our aim is to meta-analyze controlled trials withhomogeneous samples that allow us to explain the inconsistency of the resultsobtained so far. After reviewing 1525 articles, two independent reviewersidentified 7 studies that met very restrictive criteria to ensure homogeneity of thesamples. The results indicated that patients treated with interventions of provenefficacy for the depression, reduce their levels of depressive disorder significantlymore than subjects without this treatment and that there are significantdifferences in the number of patients who reduce depressive symptoms in clinically relevant way. In addition, fewer adverse cardiovascular events wereobserved during treatment, although this difference was minimally significant andwas not maintained after the follow-up. These results suggest that theinconsistency of the currently available data could be due to methodologicaldifficulties evidencing the need for further research to clarify the effect ofdepression treatment on post-ACS prognosis.K EY WORDS : coronary heart disease, acute coronary syndrome, depressiontreatment, meta-analysis.(AU)

El papel de la impulsividad en la orientación al suicidio de universitarios con antecedentes de conducta autolesiva / The role of impulsivity in suicidal orientation of university students with a history of self-injurious behavior

El objetivo de esta investigación fue describir el efecto de la depresión, la desesperanza y la impulsividad sobre la orientación al suicidio y el papel de la impulsividad como mediador de la orientación suicida en universitarios con antecedentes de conductas autolesivas. Participaron 1.645 jóvenes entre los 18 y 29 años, de dos ciudades colombianas. Se seleccionaron 218 jóvenes (M= 21,00; DT= 2,99) que informaron de al menos un intento de suicidio en el último año, quienes contestaron el “Inventario de orientación suicida”, la “Escala de desesperanza de Beck”, el “Inventario de depresión de Beck” y la “Escala de impulsividad de Barratt”. La depresión, la desesperanza y la impulsividad explicaron el 63% de la variación de la orientación al suicidio (R2= 0,635; IC 95% [0,555; 0,713]; p= 0,001). La impulsividad medió con depresión en aquellos casos en los que la orientación suicida era alta, cuyos efectos totales, directos e indirectos, fueron estadísticamente significativos (p< 0,001). La impulsividad desempeña un papel mediador entre la depresión y la desesperanza en la predicción de la orientación suicida.(AU)

The aim of this research was to describe the effect of depression,hopelessness, and impulsivity on orientation to suicide and the role of impulsivityas a mediator of suicidal orientation in university students with a history of self-injury behaviors. 1645 young people between 18 and 29 years old participated,from two Colombian cities. 218 young people were selected (M= 21.00; SD= 2.99)who reported at least one suicide attempt in the last year, who answered the“Suicidal Orientation Inventory”, the “Beck Hopelessness Scale”, the “BeckDepression Inventory” and the “Barratt Impulsivity Scale”. Depression,hopelessness, and impulsivity explained 63% of the variation in suicidal orientation (R 2 = .635, IC 95% [.555, .713], p= .001). Impulsivity mediated with depression inthose cases in which suicidal orientation was high, whose total, direct and indirecteffects were statistically significant (p< .001). Impulsivity plays a mediating rolebetween depression and hopelessness in predicting suicidal orientation.K EY WORDS : depression, hopelessness, impulsivity, suicidality, college youth.(AU)

Asociación entre niveles de ansiedad y depresión en adultos con obesidad / Associação entre níveis de ansiedade e depressão em adultos com obesidade / Association between anxiety levels and depression in adults with obesity

Objetivo: Verificar la asociación entre los niveles de ansiedad y depresión en participantes de un Programa Multidisciplinario para el Tratamiento de la Obesidad, con variables antropométricas; composición corporal; parámetros bioquímicos y hemodinámicos; y aptitud física relacionada con la salud. Método: Estudio cuantitativo, correlacional, transversal, realizado con adultos participantes del Programa Multidisciplinario de Tratamiento de la Obesidad en un municipio del Noroeste de Paraná. Para la recolección de datos se aplicaron medidas antropométricas en julio de 2021; composición corporal; parámetros bioquímicos y hemodinámicos; pruebas de aptitud física relacionadas con la salud; y escala para evaluar los niveles de ansiedad y depresión. Resultados: Participaron del estudio 116 individuos, 87,94% mujeres, 12,06% hombres, con una edad media de 40 años. Hubo una correlación positiva considerable entre la hemoglobina y el hematocrito; colesterol total y LDL; glucosa y HbA1C1; peso e IMC; peso y perímetro abdominal; peso y circunferencia de la cintura; IMC y perímetro abdominal; IMC y perímetro de cintura; así como ansiedad y depresión. Conclusión: Los niveles de ansiedad y depresión de los participantes de Programa Multidisciplinario para el Tratamiento de la Obesidad no se correlacionaron significativamente con las variables de medición antropométricas; composición corporal; parámetros bioquímicos y hemodinámicos; y pruebas de evaluación de la aptitud física relacionadas con la salud. (AU)

Objetivo: Verificar associação entre níveis de ansiedade e depressão de participantes de um Programa Multiprofissional de Tratamento da Obesidade, com variáveis antropométricas; composição corporal; parâmetros bioquímicos e hemodinâmicos; e aptidão física relacionada à saúde. Método: Estudo transversal, realizado com adultos que participaram do programa em município do Noroeste do Paraná. Para a coleta de dados, aplicou-se em julho de 2021, avaliações de medidas antropométricas; composição corporal; parâmetros bioquímicos e hemodinâmicos; testes de aptidão física relacionada à saúde; e escala para avaliar os níveis de ansiedade e depressão. Resultados: Participaram do estudo 116 indivíduos, sendo 87,94% do sexo feminino, 12,06% do sexo masculino, com média de idade de 40 anos. Houve correlação positiva entre hemoglobinas e hematócritos; colesterol total e LDL; glicose e HbA1C1; peso, IMC e circunferências abdominal e de cintura; além de ansiedade e depressão. Conclusão: Os níveis de ansiedade e depressão não apresentaram correlação significativa com as variáveis estudadas. (AU)

Objective: To verify the association between levels of anxiety and depression of participants in a Multidisciplinary Program for the Treatment of Obesity, with anthropometric variables; body composition; biochemical and hemodynamic parameters; and health-related physical fitness. Method: Quantitative, correlational, cross-sectional study carried out with adults who participated in the Multidisciplinary Program for the Treatment of Obesity in a municipality in the Northwest of Paraná. For data collection, anthropometric measurements were applied in July 2021; body composition; biochemical and hemodynamic parameters; health-related physical fitness tests; and scale to assess levels of anxiety and depression. Results: 116 individuals participated in the study, 87.94% female, 12.06% male, with a mean age of 40 years. There was a considerable positive correlation between hemoglobin and hematocrit; total and LDL cholesterol; glucose and HbA1C1; weight and BMI; weight and abdominal circumference; weight and waist circumference; BMI and abdominal circumference; BMI and waist circumference; as well as anxiety and depression. Conclusion:The levels of anxiety and depression of the participants of the Multidisciplinary Program for the Treatment of Obesity did not present a significant correlation with the variables of anthropometric measurements; body composition; biochemical and hemodynamic parameters; and health-related physical fitness assessment tests. (AU)

Quality of life, adherence to voice rehabilitation therapy and psychological variables in patients with head and neck cancer / Calidad de vida, adherencia al tratamiento de rehabilitación de voz y variables psicológicas en pacientes con cáncer de cabeza y cuello

Introduction: Voice problems can affect quality of life (QoL), other psychological aspects, and the adequate adherence to voice rehabilitation therapy. Objective: To determine the association between QoL and treatment adherence (TA) to voice rehabilitation with symptoms of anxiety, depression, and coping strategies. Method: A longitudinal study was conducted with 97 participants with head and neck cancer (H&N) who were attending voice rehabilitation therapy. Instruments: EORTC QLQ-C30 and QLQ-H&N35, Treatment Adherence Checklist, Cancer Coping Questionnaire and HADS. Results: The mean overall QoL was 83.33, and mean TA was 8.80. Lower overall QoL and emotional functioning scores, as well as higher dry mouth scores were associated with higher levels of anxiety. Greater problems with social contact and lower TA were associated to higher depression scores. Conclusion: Consistent with the literature, TA and QoL were associated to depression and QoL was also correlated to anxiety. These results are among the first to explore such aspects in Latino patients and emphasize the importance of multidisciplinary care for H&N cancer patients in voice rehabilitation therapy, given that during their treatment they may encounter psychological barriers that could hinder their progress in voice quality and QoL.(AU)

Introducción: Los problemas de la voz pueden afectar la calidad de vida (CV) y otros aspectos psicológicos, así como la adecuada adherencia a la terapia de rehabilitación de voz. Objetivo: Determinar la relación entre la CV y la adherencia al tratamiento (AT) de rehabilitación de voz con síntomas de ansiedad, depresión y estrategias de afrontamiento. Método: Se realizó un estudio longitudinal en 97 participantes con cáncer de cabeza y cuello (CyC) que asistían a terapia de rehabilitación de voz. Instrumentos: EORTC QLQ-C30 y QLQ-H&N35, Lista de Verificación de Adherencia al Tratamiento, la Escala de Afrontamiento al Cáncer y la HADS. Resultados: La CV global promedio fue de 83.33 y el puntaje promedio de AT fue de 8.80. La calidad de vida global, la función emocional y boca seca se asociaron con la ansiedad. La dimensión de la CV contacto social y la AT tuvieron relación con la depresión. Conclusiones: Consistente con la literatura la AT y la CV tuvieron relación con la depresión y solo la CV se relacionó con la ansiedad. Los resultados presentados son de los primeros en explorar estos aspectos en pacientes latinos y enfatizan la importancia de la atención multidisciplinaria a pacientes con cáncer de CyC en terapia de rehabilitación de voz, dado que en el curso de sus tratamientos pueden encontrar barreras psicológicas que obstaculicen la mejora en la calidad de la voz y la CV.(AU)

Salud mental asociada a la pandemia de COVID-19 en estudiantes de fisioterapia de la Universidad Nacional Autónoma de México / Mental health associated with the COVID-19 pandemic in physiotherapy students at the National Autonomous University of Mexico

Antecedentes y objetivo: A nivel mundial la pandemia por el COVID-19 ha interrumpido el aprendizaje de más de mil millones de estudiantes, quienes reportan alteraciones en la salud mental, niveles altos de estrés académico y carga de trabajo. En la Licenciatura en Fisioterapia de la Universidad Nacional Autónoma de México, 331 estudiantes dejaron de asistir a clases presenciales indispensables para su formación académica y, tras un año de confinamiento, se desconoce el impacto psicológico y académico en esta población. El objetivo fue evaluar la salud mental, carga de trabajo y estrés académico de los estudiantes e identificar la asociación entre variables. Materiales y métodos: Se aplicó el Cuestionario de Salud Emocional por la Pandemia de COVID-19 - Fisioterapia, la escala de carga de trabajo UNIPSICO Battery y el Cuestionario de estrés estudiantil COVID-19. Se incluyeron los alumnos inscritos entre el primer y cuarto año de la Licenciatura en Fisioterapia de la Universidad Nacional Autónoma de México mayores de 18 años que contestaron la encuesta vía online y otorgaron su consentimiento informado. Resultados: El 62,7% de los estudiantes reportaron ansiedad, el 61,8% reportaron depresión, el 51,0% indicaron una percepción moderada del estrés académico y el 42,2% percibieron una carga de trabajo alta. La ansiedad y depresión tuvieron una asociación estadísticamente significativa con el estrés académico y carga de trabajo (p<0,05). Conclusiones: El estudio evidencia los efectos psicológicos y académicos derivados de la pandemia del COVID-19 en estudiantes de fisioterapia, que amerita medidas de intervención fisioterapéuticas y académicas que mitiguen los efectos del confinamiento.(AU)

Background and objective: Worldwide, the COVID-19 pandemic has disrupted the learning of over a billion students, who report mental health disorders, high levels of academic stress, and workload. In the bachelor's degree in physical therapy at the National Autonomous University of Mexico, 331 students stopped attending essential face-to-face classes for their academic training, and after a year of confinement, the psychological and academic impact on this population is unknown. The objective was to evaluate the mental health, workload, and academic stress of students in the bachelor's degree and identify the association between variables. Materials and methods: The Emotional Health Questionnaire for the COVID-19 pandemic – physical therapy was applied, including the UNIPSICO battery workload scale and the COVID-19 student stress questionnaire. Students enrolled between the first and fourth year of the Bachelor's degree in Physical Therapy at the National Autonomous University of Mexico over 18 years old who completed the survey online and provided informed consent were included. Results: 62.7% of students reported anxiety, 61.8% reported depression, 51.0% indicated a moderate perception of academic stress, and 42.2% perceived a high workload. Anxiety and depression had a statistically significant association with academic stress and workload (P<.05). Conclusions: The study demonstrates the psychological and academic effects of the COVID-19 pandemic on physical therapy students, which warrants physiotherapeutic and academic intervention measures to mitigate the effects of confinement.(AU)

The Moderating Role of Perceived Efficacy of COVID-19 Prevention Measures on the Relation Between Perceived Risk and Perceived Mental Health / El rol moderador de la eficacia percibida de las medidas de prevención frente al COVID-19 en la relación entre la percepción de riesgo y la salud mental percibida

La pandemia del COVID-19 ha llevado a los países a adoptar severas y prolongadas medidas que —junto con el alto número de contagios y muertes y la continua información negativa— ha afectado la salud mental de las personas. Este estudio analiza el impacto de la crisis sanitaria del COVID-19 en España explorando el rol moderador de la eficacia percibida de las medidas de contención en la relación que establece la percepción del riesgo del COVID-19 con el estrés y la depresión. Un total de 478 adultos residentes en España (un 66.9% mujeres; Medad = 36.30, DT = 15.32) completaron un cuestionario con escalas concebidas para medir el riesgo percibido del COVID-19, la eficacia percibida de las medidas de protección, el estrés y la depresión entre el 16 de mayo y el 6 de junio de 2021. Los resultados confirmaron el rol moderador de la eficacia percibida, la cual actuó como un factor protector del estrés y la depresión al disminuir el impacto negativo que la percepción de riesgo del COVID-19 tiene en ambas variables relacionadas con el distrés mental. La percepción que tienen los individuos sobre la efectividad de las medidas de protección parece ser un factor protector relevante en relación con la salud mental durante una pandemia. Se subraya la relevancia de intervenciones psicológicas y de políticas gubernamentales que mejoren la comunicación positiva del riesgo y la información adecuada sobre la eficacia de las medidas de protección.(AU)

The pandemic situation caused by COVID-19 led countries to adopt harsh and prolonged (over time) measures that—along with the high number of infections and deaths and continuous negative information—have affected the mental health of individuals. In this study, the impact on mental health of the COVID-19 health crisis in Spain was explored through the perceived efficacy of pandemic containment measures as a moderator of the relationship that COVID-19 perceived risk establishes with stress and depression. A questionnaire composed of scales conceived to measure COVID-19 perceived risk, perceived efficacy of COVID-19 prevention measures, stress, and depression was completed by 478 adults living in Spain (66.9% females, Mage= 36.30, SD= 15.32) between May 16, 2021, and June 6, 2021. The results confirmed the moderating role of per-ceived efficacy. Perceived efficacy acted as a protective factor for stress and depression by decreasing the negative impact that perceived risk had on both variables related to mentaldistress. Also, the perception that par-ticipants had about the effectiveness of prevention measures appeared to be a relevant protective factor regarding mental health during the pandem-ic. This study highlights the relevance of psychological interventions and government policies that improve positive risk communication and pro-vide adequate information regarding the effectiveness of health-prevention measures.(AU)

Adaptación y validación de la Patient Health Questionnaire for Depression and Anxiety (PHQ-4) en una muestra de quechua hablantes peruanos

Introducción: El Patient Health Questionnaire for Depression and Anxiety (PHQ-4) es una medida de autoinforme ultrabreve de síntomas depresivos y ansiosos. El PHQ-4 no ha sido adaptado ni validado en la población quechua hablante. Objetivo: Este estudio tuvo como objetivo adaptar y validar el PHQ-4 en una muestra de población peruana quechua hablante en su variante Collao de Puno-Perú. Metodología: Participaron 221 personas hablantes de quechua variante collao (promedio de edad de 31,2 años, SD = 11,7, 47,1 % hombres y 52,9 % mujeres). Se evaluó la evidencia de validez basada en la estructura interna, mediante el análisis factorial confirmatorio (CFA), la fiabilidad con el método de consistencia interna y las características de dificultad y discriminación de los ítems en base a la Teoría de Respuesta al Ítem (IRT). Resultados: Los resultados indicaron que todos los ítems del PHQ-4 son relevantes, coherentes y claros para representar adecuadamente los síntomas de ansiedad y depresión. El resultado del AFC apoyó un modelo unifactorial, donde los ítems de ansiedad y depresión conforman una sola variable latente con una fiabilidad alta. Todos los ítems del PHQ-4 presentas buenos parámetros de discriminación y los parámetros de dificultad indican que los ítems son comparativamente difíciles. Por lo tanto, se necesita una mayor presencia del rasgo latente (ansiedad y depresión) para responder las categorías de respuesta más altas. Discusión: En conclusión, la PHQ-4 presentó buenas propiedades psicométricas como una medida de detección primaria rápida, confiable y válida para personas quechuahablantes que necesitan una evaluación profunda, monitoreo de los síntomas para diagnóstico y tratamiento para la ansiedad o depresión.

Introduction: The Patient Health Questionnaire for Depression and Anxiety (PHQ-4) is an ultra-brief self-report measure of depression and anxiety symptoms. The PHQ-4 has not been adapted or validated in the Quechua-speaking population. Objective: This study aimed to adapt and validate the PHQ-4 in a sample of the Peruvian Quechua-speaking population with its Collao variant from Puno-Peru. Methods: A total of 221 Quechua speakers of the Collao variant (mean age 31.2 years, SD = 11.7, 47.1% male and 52.9% female) participated. Evidence of validity based on internal structure was evaluated using confirmatory factor analysis (CFA), reliability using the internal consistency method, and item difficulty and discrimination characteristics based on Item Response Theory (IRT). Results: The results indicated that all items of the PHQ-4 were relevant, consistent, and clear enough to adequately represent anxiety and depressive symptoms. The CFA results supported a one-factorial model, in which anxiety and depression items form a single latent variable with high reliability. All items of the PHQ-4 had good discrimination parameters, and the difficulty parameters indicated that the items were comparatively difficult. Therefore, a higher presence of the latent trait (anxiety and depression) is needed to answer higher response categories. Discussion: In conclusion, the PHQ-4 presented good psychometric properties as a rapid, reliable, and valid primary screening measure for Quechua speakers in need of in-depth assessment and symptom monitoring for the diagnosis and treatment of anxiety and depression.

[Correlation between physical activity and the symptoms of depression in senior centers in Lima, Peru]. / Correlación entre la actividad física y la sintomatología depresiva en centros integrales del adulto mayor de Lima, Perú.

BACKGROUND AND OBJECTIVE: Depression in the elderly is a growing problem, and exercise is a strategy to prevent it. We aim to identify the correlation between scores obtained in the Geriatric Depression Scale - 15 items (GDS-15) for depressive symptomatology and Metabolic equivalent of task (MET) obtained in the International Physical Activity Questionnaire - Short Form (IPAQ-S) for physical activity in aged attending senior centers in a district of Lima, Peru. METHODS: We conducted a cross-sectional study in three senior centers in Miraflores, Lima, Peru. Participants (n=158) completed a three-part questionnaire, including a sociodemographic survey to collect general participant data, the GDS-15 to assess the level of depressive symptomatology, and the IPAQ-S to evaluate the amount of physical activity performed in the last week. RESULTS: A mild but significant inverse linear correlation was identified between the GDS-15 score and METs obtained in the IPAQ-S (rho=-0.213, p=0.007). Moderate to severe depressive symptomatology decreased with a higher level of physical activity: 4.3% low level, 3.3% moderate level, and no cases in those with vigorous activity; however, these differences were not significant (p=0.541, Kendall's Tau B test). CONCLUSIóN: The results showed that individuals with moderate to severe depressive symptoms show a lower level of depressive symptoms in relation to the degree of physical activity carried out in the last week.

Cost-effectiveness and cost-utility study of a psychoeducational group intervention for people with depression and physical comorbidity in primary care.

OBJECTIVE: To evaluate the cost-effectiveness and cost-utility of a psychoeducational group intervention led by primary care (PC) nurses in relation to customary care to prevent the depression and improve quality of life in patients with physical comorbidity. DESIGN: Economic evaluation based on data from randomized, multicenter clinical trial with blind response variables and a one-year follow-up, carried in the context of the PSICODEP study. LOCATION: 27 PC teams from Catalonia. PARTICIPANTS: >50 year-old patients with depression and some physical comorbidity: diabetes mellitus type 2, ischemic heart disease, chronic obstructive pulmonary disease, and/or asthma. INTERVENTION: 12 psychoeducational group sessions, 1 per week, led by 2 PC nurses with prior training. MEASUREMENTS: Effectiveness: depression-free days (DFD) calculated from the BDI-II and quality-adjusted life years (QALYs) from the Euroqol-5D. Direct costs: PC visits, mental health, emergencies and hospitalizations, drugs. Indirect costs: days of temporary disability (TD). The incremental cost-effectiveness ratios (ICER), cost-effectiveness (ΔCost/ΔDLD) and cost-utility (ΔCost/ΔQALY) were estimated. RESULTS: The study includes 380 patients (intervention group [IG] = 204; control group [CG] = 176). 81.6% women; mean age 68.4 (SD = 8.8). The IG had a higher mean cost of visits, less of hospitalizations and less TD than the CG. The difference in costs between the IG and the CG was -357.95€ (95% CI: -2026.96 to 1311.06) at one year of follow-up. There was a mean of 11.95 (95% CI: -15.98 to 39.88) more DFD in the IG than in the CG. QALYs were similar (difference -0.01, 95% CI -0.04 to 0.05). The ICERs were 29.95€/DLD and 35,795€/QALY. CONCLUSIONS: Psychoeducational intervention is associated with an improvement in DFD, as well as a reduction in costs at 12 months, although not significantly. QALYs were very similar between groups.

Levels of depression and self-esteem in women with cancer of the endometrium and cervix receiving chemotherapy treatment in Türkiye.

OBJECTIVE: Endometrium and cervical cancer is a common and important health problem that affects women in many physical, emotional and psychological aspects. This study aimed to determine the levels of depression and self-esteem in women with endometrial and cervical cancer receiving chemotherapy, determine the factors affecting them, and examine the relationship between the levels of depression and self-esteem. METHODS: This descriptive and cross-sectional study was conducted with 158 women who came to the gynecology-oncology policlinic and chemotherapy unit of a training and research hospital in Izmir, western Türkiye, between April 2022 and April 2023. Data were collected with the "Descriptive Information Form", "Beck Depression Inventory" and "Rosenberg Self-Esteem Scale". Descriptive and inferential statistics were performed to analyse the association between the study variables. RESULTS: In this study, 52.5% of women were diagnosed with endometrial cancer and 47.5% with cervical cancer. Beck Depression Inventory mean total score was 11.28 ±â€¯6.35, and 20.3% of them were at risk of depression (BDI ≥ 17). Rosenberg Self-Esteem Scale mean total score was 21.06 ±â€¯3.85, and 97.5% of them had high self-esteem. There was a statistically significant and strong negative correlation between the mean total scores of the Beck Depression Inventory and Rosenberg Self-Esteem Scale (r = 0.723; p < 0.05). It was determined that an increase in the Rosenberg Self-Esteem Scale mean total score by 1 unit decreased the Beck Depression Inventory mean total score by 1.2 units and was responsible for 52% of the variance (B = -1.192; R2 = 0.523). CONCLUSION: It was determined that one-fifth of women experienced moderate/severe depression and the majority of them had high self-esteem. The increase in women's depression levels decreased their self-esteem. Health professionals and oncology nurses should perform screenings to determine the depression and self-esteem levels of women with endometrial and cervical cancer and provide necessary education, counseling, and care to women.

A sex-specific pathway linking early life maltreatment, vagal activity, and depressive symptoms.

Background: Experiences of early life maltreatment (ELM) are alarmingly common and represent a risk factor for the development of psychopathology, particularly depression. Research has focused on alterations in autonomic nervous system (ANS) functioning as a mediator of negative mental health outcomes associated with ELM. Early alterations in autonomic vagal activity (vmHRV) may moderate the relationship between ELM and depression, particularly when considering forms of emotional maltreatment. Recent evidence suggests that the relationships of both ELM and vmHRV with depression may be non-linear, particularly considering females.Objective: Building on and extending theoretical considerations and previous work, the present work aims to further the current understanding of the complex relationships between ELM exposure, vmHRV, and depression.Methods: This study uses an adaptive modelling approach, combining exploratory network-based analyses with linear and quadratic moderation analyses, drawing on a large sample of males and females across adolescence (total N = 213; outpatient at-risk sample and healthy controls) and adulthood (total N = 85; community-based convenience sample).Results: Exploratory network-based analyses reveal that exposure to emotional abuse is particularly central within a network of ELM subtypes, depressive symptoms, and concurrent vmHRV in both adolescents and adults. In adults, emotional neglect shows strong associations with both emotional abuse and vmHRV and is highly central as a network node, which is not observed in adolescents. Moderator analyses reveal significant interactions between emotional maltreatment and vmHRV predicting depressive symptoms in adult females. Significant quadratic relationships of emotional maltreatment and vmHRV with depression are observed in both adolescent and adult females.Conclusions: The present findings contribute to the understanding of the psychological and physiological mechanisms by which ELM acts as a risk factor for the development of depression. Ultimately, this will contribute to the development of targeted and effective intervention strategies to mitigate the detrimental effects of early adversity.

Early exposure to chronic and severe adversity, which includes experiences of maltreatment, defined by the World Health Organization as physical, sexual, emotional abuse and/or neglect of children under the age of 18, is highly prevalent in the general population (estimated at 40­50 percent), and is a well-documented risk factor for depression.The present work combines network-based analyses with tests of different functions (i.e. linear, nonlinear quadratic) in moderator analyses to further explore the complex relationships among ELM exposure, vmHRV, and depression.The present findings contribute to the understanding of the psychological and physiological mechanisms by which early exposure to chronic and severe maltreatment acts as a risk factor for the development of depression.Ultimately, this will contribute to the development of targeted and effective intervention strategies to mitigate the detrimental effects of early adversity.

Estudio transversal comparativo sobre alimentación emocional en tres poblaciones universitarias de la Península Ibérica / Emotional eating in university students: a cross-sectional and comparative study in the Iberian Peninsula

Fundamentos: aunque la falta de avances en la reducción de la obesidad supone un problema mundial, cada lugar presenta diferentes factores contribuyentes. Uno de los que contribuyen actualmente al aumento de la prevalencia de la obesidad es la ali-mentación emocional. El objetivo de este trabajo fue describir y comparar el nivel de alimentación emocional y analizar qué variables y en qué medida afectaban al resto de las variables.métodos: se realizó un estudio descriptivo transversal en alumnado de tres universidades de la península ibérica (n=1.654) entre octubre de 2019 y junio de 2020. Los datos se recogieron a través de un cuestionario online de autoinforme en el cual se incluyeron datos sociodemográficos y antropométricos, así como cuestionarios validados como el cuestionario de comedores emocionales, el shortform-36 y el cuestionario hospitalario de ansiedad y depresión. Se realizó un muestreo aleatorio estratificado por grupos de facultad, titulación y clase. Para los resultados descriptivos, se calcularon las medias, la desviación estándar y las frecuencias relativas de las variables. Para comparar las medias se utilizaron la prueba t de student, chi-cuadrado y anova. Se realizaron regresiones lineales simples y múltiples para ambas muestras.resultados: la puntuación media en alimentación emocional fue de 8,77±5,66 para el alumnado de españa y de 10,02±6,19 para el de portugal, con una diferencia de 3,62 (<0,001). En españa, la variable dependiente que más afectó a la alimentación emocional fue la calidad de vida (13,8% de varianza [<0,001]), mientras que en portugal fue la ansiedad (10,1% de varianza [<0,001]).conclusiones: se encuentran diferencias estadísticamente significativas en el nivel de alimentación emocional entre poblacio-nes. Además, existe disimilitud en las variables que influyen en el principal en ambos países. Estos hallazgos implican que deben ser considerados en el diseño de futuras investigaciones o intervenciones sanitarias.(AU)

Background: although the lack of progress in reducing obesity is a global problem, different places have different contributing factors. One of the factors currently contributing to the increasing prevalence of obesity is emotional eating. The aim of this paper was to describe and compare the level of emotional eating and to analyse which variables and to what extent they affected the other variables.methods: a descriptive cross-sectional study was conducted in students from 3 universities of the iberian peninsula (n=1,654) between october 2019 and june 2020. Data were collected through an online self-report questionnaire which included sociodemographic and anthropometric data and validated questionnaires such as: the emotional eaters questionnaire, the shortform-36 and the hospital anxiety and depression questionnaire. Stratified random sampling was performed by faculty, degree, and class groups. For descriptive results, means, standard deviation and relative frequencies of variables were calculated. Student’s t-test, chi-square and anova were used to compare means. Simple and multiple linear regressions were performed for both samples.results: the mean emotional eating score was 8.77±5.66 for spanish students and 10.02±6.19 for portuguese students, with a difference of 3.62 (<0.001). In spain, the dependent variable that most affected emotional eating was quality of life (13.8% variance [<0.001]), while in portugal it was anxiety (10.1% variance [<0.001]).conclusions: statistically significant differences are found in the level of emotional eating between populations. In addition, there is dissimilarity in the variables influencing the principal in both countries. These findings imply that they should be considered in the design of future research or health interventions.(AU)

La long covid y su impacto en el funcionamiento mental / [The long covid and its impact on mental functioning]

La Covid-19 es una enfermedad causada por el virus SARS-Cov-2. Más allá de los síntomas respiratorios característicos de la enfermedad, se produce una afectación multisistémica, que incluye al Sistema Nervioso Central (SNC). El 15.2% de las personas infectadas experimentan la persistencia de los síntomas o el desarrollo de nuevos síntomas relacionados con la infección tras la recuperación de la fase aguda. La fatiga y el deterioro cognitivo destacan entre los síntomas principales de las personas con Long Covid/Covid Persistente, quienes refieren sobre todo dificultades atencionales, mnésicas y ejecutivas. Este conjunto de síntomas cognitivos ha recibido el término de “niebla mental”. Todo ello, junto a las alteraciones psicopatológicas - ansiedad, depresión y/o trastornos del sueño - tiene un impacto significativo en el funcionamiento diario y en la calidad de vida de las personas afectadas. El progreso en el conocimiento de los síntomas mentales de la Long Covid es imprescindible para diseñar intervenciones terapéuticas. Su reconocimiento también es importante en la valoración de la capacidad laboral. El objetivo de esta revisión es presentar de forma didáctica la información disponible sobre disfunción cognitiva y alteraciones psicopatológicas post Covid-19. (AU)

Covid-19 is a disease caused by the SARSCov-2 virus. Beyond the respiratory symp toms characteristic of the disease, there is multisystem involvement, including the Central Nervous System (CNS). 15.2% of infected people experience persistence of symptoms or development of new infection-related symptoms after recovery from the acute phase. Fatigue and cognitive impairment are among the main symptoms of people with Long Covid/Persistent Covid, who report mainly attentional, memory and executive difficulties. This set of cognitive symptoms has been given the term "brain fog". Together with psychopathological disturbances - anxiety, depression and/or sleep disorders - they have a significant impact on the daily functioning and quality of life of those affected. Progress in the knowledge of the mental symptoms of Long Covid is essential to design therapeutic interventions. Their recognition is also important in the assessment of work capacity. The aim of this review is to present in a didactic way the available information on cognitive dysfunction and psychopathological alterations post Covid-19. (AU)

Health Behaviors and Sleep Quality in Portuguese Adolescents: The Moderating Role of Age and Gender / [Los comportamientos relativos a la salud y la calidad del sueño en los adolescentes portugueses: el efecto moderador de la edad y del sexo]

Background: Adolescence is marked by changes such as sleep and health behaviors. This study analyzed the relationships and differences on excessive daytime sleepiness, anxiety and depression symptoms, sleep habits, family sleep behaviors, sleep quality and health behaviors in adolescents including the moderating effect of adolescents’ age and gender. Method: The sample included 272 adolescents, 58% being female. Results: Girls and older adolescents reported worse sleep quality. Older adolescents reported healthier behaviors. Female gender, having a family member with sleep quality problems, coffee intake, anxiety and depression symptoms, daytime sleepiness, and family sleep behaviors contributed to worse sleep quality. Father’s alcohol consumption, anxiety and depression symptoms and family sleep behaviors contributed to adolescents’ sleep habits. Being a girl and an older adolescent were moderators in the relationship between the presence of excessive daytime sleepiness and worse sleep quality. Conclusions: Findings highlight the importance of health promotion programs regarding sleep quality.(AU)

Antecedentes: La adolescencia está marcada por los cambios en el sueño y comportamientos referidos a la salud. Este estudio analizó las relaciones y diferencias en la somnolencia diurna excesiva, los síntomas de ansiedad y depresión, los hábitos de sueño, los comportamientos de sueño familiares, la calidad del sueño, los comportamientos de salud en adolescentes, incluido el efecto moderador de la edad y el sexo de los adolescentes. Método: La muestra de este estudio estaba compuesta por 272 adolescentes, siendo el 58% de sexo femenino. Resultados: Las niñas y los adolescentes mayores indicaron una peor calidad del sueño. Los adolescentes mayores manifestaron comportamientos más saludables. Ser de sexo femenino, tener un familiar con problemas de sueño, consumir café, tener síntomas de ansiedad y depresión, así como somnolencia diurna y conductas de sueño familiares se asocian con una peor calidad del sueño. El consumo de alcohol del padre, los síntomas de ansiedad y depresión y las conductas de sueño familiares se asocian con los hábitos de sueño de los adolescentes. Ser niña y adolescente de mayor edad modera la relación entre la presencia de somnolencia diurna excesiva y peor calidad del sueño. Conclusiones: Los resultados resaltan la importancia de los programas de promoción de la salud en relación con la calidad del sueño.(AU)

Ayahuasca e saúde mental: efeitos do seu uso associado a casos de depressão / Ayahuasca and mental health: effects of its use in association with depresion cases / Ayahuasca y salud mental: efectos de sue uso en asociación con casos de depressión

O aumento de casos de depressão na população mundial leva ao questionamento sobre a eficácia dos tratamentos farmacológicos e fomenta a busca por tratamentos alternativos. Estudos a respeito da ayahuasca e seus efeitos na depressão vêm sendo realizados. Por meio de uma revisão integrativa, a partir da questão norteadora: "Quais são os efeitos da ayahuasca em indivíduos com depressão?", neste estudo buscou-se: (1) identificar potenciais usos terapêuticos do chá de ayahuasca; (2) analisar as características de segurança e riscos à saúde no seu uso; (3) investigar se o contexto do uso influencia seus efeitos. A busca de artigos foi realizada nas bases BVS e PubMed, produzidos entre 2017-2022, resultando em 8 artigos para análise. Os estudos evidenciaram efeitos antidepressivos advindos das interações neuroquímicas e das experiências psicológicas por meio da ayahuasca e apresentaram que a segurança e potencial terapêutico estão atrelados ao contexto de uso e à dosagem ingerida do chá (AU).

The increase in cases of depression in the world's population leads to questioning the effectiveness of pharmacological treatments and encourages the search for alternative treatments. Studies about ayahuasca andyour effectsondepressionhavebeenconducted. Guided by the question: "What are the effects of ayahuasca in individuals with depression?" this study was a integrativereview that aimed to: (1) identify potential therapeutic uses of ayahuasca tea;(2) analyzethesafetycharacteristics andhealthrisks inyour use; (3) investigatewhetherthecontextofuseinfluences your effects.The search for articles was conducted in the BVS and PubMed databases, produced between 2017-2022, resulting in 8 articles for analysis. Thestudies showed antidepressanteffectsresultingfromneurochemical interactions andpsychologicalexperiences as results of the use of ayahuasca and showed that the safety and therapeutic potential are linked to the context of use and the ingested dosage of the tea (AU).

El aumento de los casos de depresión en la población mundial lleva a cuestionar la eficacia de los tratamientos farmacológicos y fomenta la búsqueda de tratamientos alternativos. Se han realizado estudios sobre la ayahuasca y sus efectos sobre la depresión. Por medio de la cuestión: "¿Cuáles son los efectos de la ayahuasca en personas con depresión?", este estudio de revisión integrativabuscó: (1) identificar los usos terapéuticos potenciales del té de ayahuasca; (2) analizar las características de seguridad y los riesgos para la salud en su uso; (3) investigar si el contexto de uso influye en sus efectos. La búsqueda de artículos se realizó en las bases de datos BVS y PubMed, producidas entre 2017-2022, resultando 8 artículos para análisis. Fueron observados en los estudios efectos antidepresivos advenidos de la ayahuasca y que la seguridad y potencial terapéutico están vinculados al contexto de uso y la dosis ingerida del té (AU).

La depresión como factor de riesgo de la demencia: fisiopatología y modelos preclínicos de estudio / Depression as a risk factor for dementia: Pathophysiology and preclinical study models

El aumento de la esperanza de vida ha llevado a un incremento en la incidencia de enfermedades crónicas como la demencia. Tratar los factores de riesgo de la demencia, como la depresión, podría reducir su incidencia. Sin embargo, el tratamiento con antidepresivos no ha sido eficaz en el manejo de este síntoma, lo que aumenta el riesgo de demencia en el futuro. Es fundamental investigar las causas y el tratamiento de la depresión, y el uso de modelos animales es importante en este sentido. Este estudio busca analizar la relación entre la depresión y el riesgo de desarrollar demencia, así como los modelos preclínicos más relevantes para estudiar la depresión en roedores. (AU)

The increase in life expectancy has led to a rise in the incidence of chronic diseases, such as dementia. Treating the risk factors of dementia, such as depression, could help reduce its occurrence. However, antidepressant treatment has not proven effective in managing this symptom, thereby increasing the risk of dementia in the future. It is essential to investigate the causes and treatment of depression, and in this regard, the use of animal models is of great significance. This study aims to analyze the evidence supporting the relationship between depression and the risk of developing dementia, while also providing an update on the most relevant preclinical models for studying depression in rodents. (AU)